This week we look at the mechanism of action of Turmeric and it’s components.  (This week is very “science”, so if you enjoy that information, then this is the week for you!).

The phenolic curcuminoid, curcumin, is one of the most potent inhibitors of the NF-KB pathway.  Activation of the NF-KB pathway induces several cell functions, including alteration of gene expression and is stimulated by inflammatory-inducing factors like infection, stress response or cell growth.  It is through regulating and normalising cell gene expression, together with reducing proliferation and increasing apoptosis in cancerous cells, turmeric establishes anti-cancer activity as well as an anti-inflammatory response.  Heart health is influenced positively by the hydro-ethanolic extract decreasing oxidation of low-density lipoprotein. Turmeric also acts as an antioxidant, specifically in renal cells, by acting as a free radical scavenger against hydrogen peroxide. It has been shown that turmeric has a positive influence in improving serum alanine aminotransferase and aspartate aminotransferase levels in non-alcoholic fatty liver disease, although the mechanism is not fully understood yet, it is thought to be due to inhibiting liver damage via the peroxisome proliferator activated receptor-gamma.

Next week we take our final look at Turmeric, looking at toxicity levels, availability and a full reference list.

Emma Manning Clinical Nutritionist

www.nutritionalbesthealth.com.au

Nutritional Consultations telehealth appointments (Health Fund Rebates available depending on your fund’s policy) and Bio Energetic Synchronisation Technique face to face sessions are available. Contact me today on 0422246231 or emmavmanning@live.com to book your appointment.